VDAC1 Back

voltage-dependent anion channel 1

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NCBI Description of VDAC1
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.

Community Annotation of VDAC1 Add / Edit VDAC1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VDAC1 is highly significantly mutated in
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VDAC1 is significantly mutated in
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VDAC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VDAC1