VCX2 Back

variable charge, X-linked 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of VCX2
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 2 repeats of the 30-bp unit.

Community Annotation of VCX2 Add / Edit VCX2: Annotations

No community annotations yet for VCX2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

VCX2 is highly significantly mutated in
(none)
VCX2 is significantly mutated in
(none)
VCX2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for VCX2