UVRAG Back

UV radiation resistance associated gene

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UVRAG
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Community Annotation of UVRAG Add / Edit UVRAG: Annotations

No community annotations yet for UVRAG.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UVRAG is highly significantly mutated in
(none)
UVRAG is significantly mutated in
(none)
UVRAG is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UVRAG