USP46 Back

ubiquitin specific peptidase 46

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NCBI Description of USP46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009].

Community Annotation of USP46 Add / Edit USP46: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


USP46 is highly significantly mutated in
USP46 is significantly mutated in
USP46 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for USP46