USP4 Back

ubiquitin specific peptidase 4 (proto-oncogene)

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NCBI Description of USP4

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of USP4 Add / Edit USP4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


USP4 is highly significantly mutated in
USP4 is significantly mutated in
USP4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for USP4