USP28 Back

ubiquitin specific peptidase 28

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NCBI Description of USP28

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008].

Community Annotation of USP28 Add / Edit USP28: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


USP28 is highly significantly mutated in
USP28 is significantly mutated in
USP28 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for USP28