USP2 Back

ubiquitin specific peptidase 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of USP2
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of USP2 Add / Edit USP2: Annotations

No community annotations yet for USP2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

USP2 is highly significantly mutated in
(none)
USP2 is significantly mutated in
(none)
USP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for USP2