USP10 Back

ubiquitin specific peptidase 10

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of USP10
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene.

Community Annotation of USP10 Add / Edit USP10: Annotations

No community annotations yet for USP10.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

USP10 is highly significantly mutated in
(none)
USP10 is significantly mutated in
(none)
USP10 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for USP10