USP1 Back

ubiquitin specific peptidase 1

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NCBI Description of USP1
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Community Annotation of USP1 Add / Edit USP1: Annotations

No community annotations yet for USP1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

USP1 is highly significantly mutated in
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USP1 is significantly mutated in
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USP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for USP1