USF1 Back

upstream transcription factor 1

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NCBI Description of USF1
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21.

Community Annotation of USF1 Add / Edit USF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

USF1 is highly significantly mutated in
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USF1 is significantly mutated in
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USF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for USF1