UPRT Back

uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)

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NCBI Description of UPRT
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UPRT is highly significantly mutated in
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UPRT is significantly mutated in
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UPRT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UPRT