UPP1 Back

uridine phosphorylase 1

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NCBI Description of UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC and thymidine phosphorylase (TP; EC, in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009].

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UPP1 is highly significantly mutated in
UPP1 is significantly mutated in
UPP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UPP1