UPK1B Back

uroplakin 1B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UPK1B
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.

Community Annotation of UPK1B Add / Edit UPK1B: Annotations

No community annotations yet for UPK1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UPK1B is highly significantly mutated in
(none)
UPK1B is significantly mutated in
(none)
UPK1B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UPK1B