UPF3B Back

UPF3 regulator of nonsense transcripts homolog B (yeast)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UPF3B

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Community Annotation of UPF3B Add / Edit UPF3B: Annotations

No community annotations yet for UPF3B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UPF3B is highly significantly mutated in
(none)
UPF3B is significantly mutated in
(none)
UPF3B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for UPF3B