UPF1 Back

UPF1 regulator of nonsense transcripts homolog (yeast)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UPF1
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Community Annotation of UPF1 Add / Edit UPF1: Annotations

No community annotations yet for UPF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UPF1 is highly significantly mutated in
(none)
UPF1 is significantly mutated in
(none)
UPF1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UPF1