UNC5B Back

unc-5 homolog B (C. elegans)

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NCBI Description of UNC5B

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.

Community Annotation of UNC5B Add / Edit UNC5B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UNC5B is highly significantly mutated in
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UNC5B is significantly mutated in
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UNC5B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for UNC5B