UHMK1 Back

U2AF homology motif (UHM) kinase 1

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NCBI Description of UHMK1

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UHMK1 is highly significantly mutated in
UHMK1 is significantly mutated in
UHMK1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UHMK1