UGT2B7 Back

UDP glucuronosyltransferase 2 family, polypeptide B7

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NCBI Description of UGT2B7

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UGT2B7 is highly significantly mutated in
UGT2B7 is significantly mutated in
UGT2B7 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UGT2B7