UGT2B28 Back

UDP glucuronosyltransferase 2 family, polypeptide B28

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NCBI Description of UGT2B28
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UGT2B28 is highly significantly mutated in
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UGT2B28 is significantly mutated in
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UGT2B28 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UGT2B28