UGT2B17 Back

UDP glucuronosyltransferase 2 family, polypeptide B17

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NCBI Description of UGT2B17

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UGT2B17 is highly significantly mutated in
UGT2B17 is significantly mutated in
UGT2B17 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UGT2B17