UGT2B15 Back

UDP glucuronosyltransferase 2 family, polypeptide B15

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NCBI Description of UGT2B15
This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UGT2B15 is highly significantly mutated in
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UGT2B15 is significantly mutated in
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UGT2B15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UGT2B15