UCHL1 Back

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

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NCBI Description of UCHL1
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

Community Annotation of UCHL1 Add / Edit UCHL1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UCHL1 is highly significantly mutated in
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UCHL1 is significantly mutated in
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UCHL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UCHL1