UBR4 Back

ubiquitin protein ligase E3 component n-recognin 4

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NCBI Description of UBR4

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.

Community Annotation of UBR4 Add / Edit UBR4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UBR4 is highly significantly mutated in
UBR4 is significantly mutated in
UBR4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UBR4