UBR2 Back

ubiquitin protein ligase E3 component n-recognin 2

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NCBI Description of UBR2

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.

Community Annotation of UBR2 Add / Edit UBR2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


UBR2 is highly significantly mutated in
UBR2 is significantly mutated in
UBR2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for UBR2