UBQLN2 Back

ubiquilin 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UBQLN2

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Community Annotation of UBQLN2 Add / Edit UBQLN2: Annotations

No community annotations yet for UBQLN2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UBQLN2 is highly significantly mutated in
(none)
UBQLN2 is significantly mutated in
(none)
UBQLN2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for UBQLN2