UBE4A Back

ubiquitination factor E4A (UFD2 homolog, yeast)

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NCBI Description of UBE4A
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UBE4A is highly significantly mutated in
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UBE4A is significantly mutated in
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UBE4A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UBE4A