UBE2R2 Back

ubiquitin-conjugating enzyme E2R 2

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NCBI Description of UBE2R2
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UBE2R2 is highly significantly mutated in
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UBE2R2 is significantly mutated in
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UBE2R2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for UBE2R2