UBE2B Back

ubiquitin-conjugating enzyme E2B (RAD6 homolog)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of UBE2B

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.

Community Annotation of UBE2B Add / Edit UBE2B: Annotations

No community annotations yet for UBE2B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

UBE2B is highly significantly mutated in
(none)
UBE2B is significantly mutated in
(none)
UBE2B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for UBE2B