TUB Back

tubby homolog (mouse)

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NCBI Description of TUB
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of TUB Add / Edit TUB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TUB is highly significantly mutated in
(none)
TUB is significantly mutated in
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TUB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TUB