TTK Back

TTK protein kinase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TTK
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

Community Annotation of TTK Add / Edit TTK: Annotations

No community annotations yet for TTK.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TTK is highly significantly mutated in
(none)
TTK is significantly mutated in
(none)
TTK is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TTK