TTC21B Back

tetratricopeptide repeat domain 21B

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NCBI Description of TTC21B
This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4.

Community Annotation of TTC21B Add / Edit TTC21B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TTC21B is highly significantly mutated in
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TTC21B is significantly mutated in
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TTC21B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TTC21B