TTC19 Back

tetratricopeptide repeat domain 19

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NCBI Description of TTC19
This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of TTC19 Add / Edit TTC19: Annotations

No community annotations yet for TTC19.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TTC19 is highly significantly mutated in
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TTC19 is significantly mutated in
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TTC19 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TTC19