TSSC4 Back

tumor suppressing subtransferable candidate 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TSSC4
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region.

Community Annotation of TSSC4 Add / Edit TSSC4: Annotations

No community annotations yet for TSSC4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSSC4 is highly significantly mutated in
(none)
TSSC4 is significantly mutated in
(none)
TSSC4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSSC4