TSPO Back

translocator protein (18kDa)

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NCBI Description of TSPO
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.

Community Annotation of TSPO Add / Edit TSPO: Annotations

No community annotations yet for TSPO.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSPO is highly significantly mutated in
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TSPO is significantly mutated in
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TSPO is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSPO