TSPAN8 Back

tetraspanin 8

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NCBI Description of TSPAN8
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.

Community Annotation of TSPAN8 Add / Edit TSPAN8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSPAN8 is highly significantly mutated in
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TSPAN8 is significantly mutated in
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TSPAN8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSPAN8