TSPAN4 Back

tetraspanin 4

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NCBI Description of TSPAN4
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of TSPAN4 Add / Edit TSPAN4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSPAN4 is highly significantly mutated in
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TSPAN4 is significantly mutated in
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TSPAN4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSPAN4