TSLP Back

thymic stromal lymphopoietin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TSLP
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.

Community Annotation of TSLP Add / Edit TSLP: Annotations

No community annotations yet for TSLP.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSLP is highly significantly mutated in
(none)
TSLP is significantly mutated in
(none)
TSLP is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSLP