TSEN34 Back

tRNA splicing endonuclease 34 homolog (S. cerevisiae)

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NCBI Description of TSEN34
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Community Annotation of TSEN34 Add / Edit TSEN34: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSEN34 is highly significantly mutated in
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TSEN34 is significantly mutated in
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TSEN34 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSEN34