TSEN2 Back

tRNA splicing endonuclease 2 homolog (S. cerevisiae)

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NCBI Description of TSEN2
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TSEN2 Add / Edit TSEN2: Annotations

No community annotations yet for TSEN2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSEN2 is highly significantly mutated in
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TSEN2 is significantly mutated in
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TSEN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSEN2