TSC22D3 Back

TSC22 domain family, member 3

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NCBI Description of TSC22D3
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.

Community Annotation of TSC22D3 Add / Edit TSC22D3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSC22D3 is highly significantly mutated in
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TSC22D3 is significantly mutated in
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TSC22D3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSC22D3