TSC22D1 Back

TSC22 domain family, member 1

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NCBI Description of TSC22D1
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of TSC22D1 Add / Edit TSC22D1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TSC22D1 is highly significantly mutated in
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TSC22D1 is significantly mutated in
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TSC22D1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TSC22D1