TRPM6 Back

transient receptor potential cation channel, subfamily M, member 6

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NCBI Description of TRPM6
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Community Annotation of TRPM6 Add / Edit TRPM6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRPM6 is highly significantly mutated in
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TRPM6 is significantly mutated in
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TRPM6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TRPM6