TRPM4 Back

transient receptor potential cation channel, subfamily M, member 4

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NCBI Description of TRPM4

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TRPM4 Add / Edit TRPM4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRPM4 is highly significantly mutated in
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TRPM4 is significantly mutated in
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TRPM4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TRPM4