TRPM1 Back

transient receptor potential cation channel, subfamily M, member 1

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NCBI Description of TRPM1

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.

Community Annotation of TRPM1 Add / Edit TRPM1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRPM1 is highly significantly mutated in
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TRPM1 is significantly mutated in
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TRPM1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TRPM1