TRPC6 Back

transient receptor potential cation channel, subfamily C, member 6

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NCBI Description of TRPC6

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Community Annotation of TRPC6 Add / Edit TRPC6: Annotations

No community annotations yet for TRPC6.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRPC6 is highly significantly mutated in
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TRPC6 is significantly mutated in
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TRPC6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TRPC6