TRPC4 Back

transient receptor potential cation channel, subfamily C, member 4

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NCBI Description of TRPC4
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of TRPC4 Add / Edit TRPC4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRPC4 is highly significantly mutated in
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TRPC4 is significantly mutated in
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TRPC4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TRPC4