TRIP6 Back

thyroid hormone receptor interactor 6

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NCBI Description of TRIP6

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Community Annotation of TRIP6 Add / Edit TRIP6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRIP6 is highly significantly mutated in
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TRIP6 is significantly mutated in
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TRIP6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TRIP6