TRIM63 Back

tripartite motif-containing 63

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NCBI Description of TRIM63

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

Community Annotation of TRIM63 Add / Edit TRIM63: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TRIM63 is highly significantly mutated in
TRIM63 is significantly mutated in
TRIM63 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TRIM63