TRIM25 Back

tripartite motif-containing 25

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NCBI Description of TRIM25
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

Community Annotation of TRIM25 Add / Edit TRIM25: Annotations

No community annotations yet for TRIM25.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRIM25 is highly significantly mutated in
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TRIM25 is significantly mutated in
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TRIM25 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TRIM25