TRIM22 Back

tripartite motif-containing 22

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TRIM22
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants.

Community Annotation of TRIM22 Add / Edit TRIM22: Annotations

No community annotations yet for TRIM22.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRIM22 is highly significantly mutated in
(none)
TRIM22 is significantly mutated in
(none)
TRIM22 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TRIM22